LSD long-term effects

LSD (lysergic acid diethylamide) is a powerful hallucinogen that causes psychological changes and intense visual and auditory hallucinations. The drug was first synthesised in 1938 and is known for its ability to alter consciousness. Often referred to as a 'psychedelic', LSD has both short-term and possible long-term effects on the body and mind. Those interested in learning more about personal experiences with LSD can check out our article on the LSD experience, but what happens when LSD is used over long periods of time?

What happens in the body?

LSD long-term effects

The long-term physical effects of LSD are relatively minor compared to many other drugs. LSD is not known as a substance-bound drug, which means that there is no classic physical dependence as with alcohol or opioids. Nevertheless, frequent use can lead to some health impairments that can become effective in the long term.

Possible physical effects of regular LSD use:

  • Cardiovascular effects: high blood pressure, increased heart rate and changes in body temperature are possible reactions to LSD.
  • Neurological changes: Some studies suggest that LSD may affect the brain in the long term, although this has not yet been fully proven.
  • Gastrointestinal problems: Some users experience nausea and stomach problems after repeated use.

LSD and mental health: long-term effects

The psychological effects of LSD can be profound and long-lasting. The mental experience of LSD can be very different with intense hallucinations and changes in perception, but what about the long-term effects on mental health?

Long-term psychological consequences:

  • HPPD (Hallucinogen Persisting Perception Disorder): One of the most well-known long-term effects of LSD is HPPD, in which those affected continue to experience hallucinations or visual changes, even long after use.
  • Mental instability: Some users report persistent anxiety or paranoid thoughts that can persist even after the trip.
  • Exacerbation of mental illness: People with a history of mental illness, such as schizophrenia or bipolarity, may experience worsening as a result of LSD use.

LSD long-term effects on the brain and cognitive performance

LSD has a strong effect on the brain and neurotransmitters related to cognition and mood. While most people do not experience permanent cognitive damage after a single use, there is evidence that prolonged or frequent use can have an effect on brain function.

  • Cognitive impairment: Some users experience difficulties with concentration, memory or problem-solving thinking after repeated use.
  • Altered perception: Long-term changes in the perception of time, space and reality can persist and affect everyday life.
Is there a dependency?

LSD and the risk of addiction

Compared to other drugs, the risk of addiction to LSD is relatively low. There is no physical dependence, as LSD does not flood the brain with dopamine, as is the case with drugs such as cocaine or heroin. However, psychological dependence can occur, where the user repeatedly turns to LSD to repeat the intense experiences.

Psychosis and other long-term psychological effects of LSD

One of the more serious long-term effects of LSD use can be the triggering of psychosis. Particularly in people who are susceptible to mental illness, LSD can exacerbate existing problems or even trigger psychosis. Psychosis can occur with delusions, hallucinations and a loss of real-life reference.

Risks of psychosis due to LSD:

  • Presence of a genetic predisposition to psychosis: if there is a family history of mental illness such as schizophrenia, there is an increased risk of long-term psychological damage.
  • Frequent use: Repeated LSD use can increase the risk of mental disorders, especially in young people.

Long-term effects of psychedelic drugs in comparison

LSD is not the only psychedelic drug that can have long-term effects on the body and mind. Other substances such as psilocybin (in magic mushrooms) or DMT also show that psychedelic drugs affect the brain in unique ways. Comparing LSD with these substances offers interesting insights into how hallucinogens work and their long-term effects.

Fazit:

LSD long-term effects and safety

The long-term effects of LSD vary greatly. While physical damage is usually minor, psychological effects such as HPPD or the aggravation of existing mental illnesses can occur. Long-term changes in perception and cognition are possible, especially with frequent use. Anyone who uses LSD should be aware of the risks and use it responsibly.